Tag Archives: DNA

Article How Oxidative Stress Shortens Telomeres

Here is an excellent article on how free radicals – oxidative stress can impact and even shorten telomeres. This is not a good thing.

Can you imagine entering the doctor’s office one day and obtaining a blood test that measures your biological age, as a better indicator of health than chronological age? That day could arrive soon with tests that measure the length of telomeres.

Images of Embryonic and Adult Stem Cells, DNA, and Telomeres
Embryonic and Adult Stem Cells, DNA, and Telomeres

Substantial evidence has led to findings that premature aging and its core cellular mechanisms are governed by the onset of telomere shortening (1-5). In this article, we hope to help increase understanding of the relationship between chronic oxidative stress and telomere instability.

The glutathione (GSH)-dependent antioxidant system is the cell’s primary defense against oxidative stress, and plays a major role in detoxification and bolstering the body’s immune system. Emerging data are helping to explain the role of the GSH-redox cycle for preserving telomeres.

Structurally, telomeres are formed by non-coding DNA sequences along with specialized proteins that act as protective caps at the physical ends of chromosomes. Human telomeric DNA consists of repeated sequences of TTAGG and extends over several thousand base pairs. Because guanine-rich sequences are more sensitive and less capable of DNA repair, telomeres are more vulnerable to oxidation.

Telomeres fold back onto themselves in a loop to provide functional stability. The telomeric DNA is synthesized by the enzyme telomerase, the absence of which results in a progressive erosion. Evidence indicates that chronic oxidative stress not only causes progressive damage to cellular membranes, proteins, and molecules, but also induces the slowing down of existing telomerase activity and accelerates telomere shortening (1&2).

Chronic oxidative stress develops into a state of progressive telomere shortening induced by elevated homocysteine levels, and reduced glutathione, or an otherwise compromised GSH-redox cycle.

Lower amounts of reduced glutathione, and diminished activity of the enzymes GSH peroxidase and catalase, cause a failure to protect cell components from damaging peroxides (1-3). The mitochondria become dysfunctional, producing increasing amounts of free radicals and less ATP energy (1-3). Together, these effects lead the cell to cease division or appropriate function, known as replicative senescence.

Guarding the GSH-antioxidant System

Because the GSH-antioxidant system is the predominant guardian against oxidative stress, it is proposed that maintaining its integrity can support against telomere erosion and “stress-induced” premature onset of accelerated aging.

Scientific research suggests that a variety of consistent behaviors in humans in-vivo are available to alter the amount of oxidative stress placed on cells of the body.

Among factors thought to adversely affect telomeres are smoking, drinking heavily, obesity, and chronic psychological stress (1-3). On the other hand, meditation, socialization, and regular exercise are associated with longer telomeres (1-3).

In addition, studies suggest diet and supplementation habits can be help preserve telomere integrity. Some choices linked with longer telomeres are:

  • consuming higher amounts of omega-3 fatty acids
  • obtaining higher amounts of vitamin D, maintaining a healthy weight, eating a diet higher in dietary fiber (particularly insoluble fiber)
  • drinking green tea regularly
  • and taking a quality multivitamin (containing sufficient amounts of B vitamins, vitamins A, C, and E) daily (4)

Whey to Glutathione

Another method to gain optimal  protection against oxidative stress and telomere attrition is by using methods to naturally increase the levels of glutathione in the body by way of regular ingestion of whey protein, according to recent studies (5-7).

Bioactive whey protein,” as one study calls it, provides a high concentration of the amino acids cysteine, glutamate, and glycine. These amino acid precursors are used in the synthesis of glutathione by the enzyme GSH-synthase. Several studies have shown that bioactive whey protein can dramatically raise the levels of glutathione in the cells of the body without side effects (5 & 6). Increases in levels of circulating glutathione from whey are associated with a stronger immune system and greater capacity of detoxification.

Whey also offers other anti-aging benefits such as protection against sarcopenia (the loss of muscle and strength with age) and by supporting weight management through increases of thermogenesis and satiety.

Supplementing to Optimize Telomere Protection

Supplementing with antioxidant vitamins and minerals supports activity of antioxidant enzymes that can assist in protecting cells and their components, including telomeres, against oxidative stress.

GSH peroxidase plays a major role using GSH as its reducing agent in detoxification of peroxides (types of reactive oxygen species, such as hydrogen peroxide), which can inflict harm to cell membranes, proteins, and telomeric DNA.

The oxidized GSH is then recycled by another enzyme, GSH reductase, which uses nicotinamide adenine dinucleotide phosphate (NADPH) as its coenzyme and reducing agent. Catalase is also an enzyme that acts as an efficient detoxifier of hydrogen peroxide, while superoxide dismutases (SOD) are a class of enzymes that act to quench superoxide, a highly reactive form of oxygen, and convert it to hydrogen peroxide or stabilized oxygen.

It’s notable that selenium, niacin, zinc, and copper are important dietary factors because these enzymes rely on them to function.

Interestingly, data are emerging that particular dietary factors and supplements could act to promote antioxidant enzyme activity further and thereby further support telomere integrity. These supplements will be subject of future blog posts.

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More Information Product B including Ordering – Click Here!

IsaGenesis – New Generation of IsaGenix Product B is Now Available

The subject line says it all.  Isagenix Co-Founder and President Jim Coover and Master Formulator John Anderson have just revealed a new formulation of Product B®!


This fourth generation of Product B is so improved, it comes with a new name—Product B IsaGenesis®—and it’s scientifically designed to deliver the optimal levels of active ingredients targeted to support telomere health.

“Isagenix cares about telomere health and we are committed to be in the forefront of this science using natural products, not drugs,” said Jim Coover during the reveal. Product B IsaGenesis aims to help telomeres do what they do best—protect your DNA, your cells and help you age healthily.

“Besides being the best telomere support product on the planet,” said John Anderson, “IsaGenesis is also a very powerful antioxidant, which benefits the liver and the brain.”

Outstanding New Improvements

  • 20 percent more active ingredients
  • Ingredients added to enhance absorption
  • It’s now a softgel, making it easier to swallow
  • Also supports liver, kidney and brain health, cell integrity and healthy circulation

The new formulation boasts another improvement: It’s now a softgel, making it easier to swallow and superior in terms of absorption of the active ingredients. “All Isagenix products are formulated with these fundamental objectives in mind,” said John Anderson also shared the origin of the product’s new name, saying, “I always knew the name would change someday as the product evolved.

Genesis means the coming into being of something, it means the origin. And that is exactly what IsaGenesis is as Isagenix leads the way to telomere health—now and in the future.” Dr. Bill Andrews, a pioneer in the world of telomere health, was also present for the reveal, where he shared some basics of telomere science and new advances in research. “As we age, our cells are constantly dividing and our telomeres shorten during the process,” Dr. Andrews explains.

“Oxidative stress, toxins and a poor diet can cause the process of telomere shortening to speed up, which means we age faster in life. And the faster we age, the sooner we face age-related health conditions down the road.”

To Order IsaGenesis – Click Here!

Then select the Products Tab And Then “Healthy Aging Solutions” and then Product B IsaGenesis. Or call us at 1-877-824-7692 -trust me it’s easier.

 

 

 

IsaGenix Product B Telomeres Product Ingredients

I have some new information about the new IsaGenix Product B Telomeres Product.
IsaGenix Product B Telomere Support with Antioxidants

Click on above highlighted webpage!

To those not familiar with what telomeres are,  first think of your body’s DNA and chromosomes. At both ends of every strand of DNA in a a human cell something called a telomere. Telomeres could be described as looking like the tail of a kite. The function of Telomeres is to prevent chromosomes from becoming frayed, fusing into rings, or binding with other DNA strands.

We obviously as the title suggests have a list of the various botanicals that comprise the Product B Telomeres Product. We will also review in subsequent posts the importance of each of these ingredients and their role in maintaining the health of telomeres.

Also on this webpage we have some additional information on telomeres and why you don’t want short telomeres.

In addition we also discuss how free radicals and oxidative stress can be so harmful toward affecting the length of your telemeres.

The new IsaGenix Product B Telomeres Product.

Label of Product B Antioxidants and Telomere Support Ingredients and More Info – Click Here!