Tag Archives: telomerase

Article How Oxidative Stress Shortens Telomeres

Here is an excellent article on how free radicals – oxidative stress can impact and even shorten telomeres. This is not a good thing.

Can you imagine entering the doctor’s office one day and obtaining a blood test that measures your biological age, as a better indicator of health than chronological age? That day could arrive soon with tests that measure the length of telomeres.

Images of Embryonic and Adult Stem Cells, DNA, and Telomeres
Embryonic and Adult Stem Cells, DNA, and Telomeres

Substantial evidence has led to findings that premature aging and its core cellular mechanisms are governed by the onset of telomere shortening (1-5). In this article, we hope to help increase understanding of the relationship between chronic oxidative stress and telomere instability.

The glutathione (GSH)-dependent antioxidant system is the cell’s primary defense against oxidative stress, and plays a major role in detoxification and bolstering the body’s immune system. Emerging data are helping to explain the role of the GSH-redox cycle for preserving telomeres.

Structurally, telomeres are formed by non-coding DNA sequences along with specialized proteins that act as protective caps at the physical ends of chromosomes. Human telomeric DNA consists of repeated sequences of TTAGG and extends over several thousand base pairs. Because guanine-rich sequences are more sensitive and less capable of DNA repair, telomeres are more vulnerable to oxidation.

Telomeres fold back onto themselves in a loop to provide functional stability. The telomeric DNA is synthesized by the enzyme telomerase, the absence of which results in a progressive erosion. Evidence indicates that chronic oxidative stress not only causes progressive damage to cellular membranes, proteins, and molecules, but also induces the slowing down of existing telomerase activity and accelerates telomere shortening (1&2).

Chronic oxidative stress develops into a state of progressive telomere shortening induced by elevated homocysteine levels, and reduced glutathione, or an otherwise compromised GSH-redox cycle.

Lower amounts of reduced glutathione, and diminished activity of the enzymes GSH peroxidase and catalase, cause a failure to protect cell components from damaging peroxides (1-3). The mitochondria become dysfunctional, producing increasing amounts of free radicals and less ATP energy (1-3). Together, these effects lead the cell to cease division or appropriate function, known as replicative senescence.

Guarding the GSH-antioxidant System

Because the GSH-antioxidant system is the predominant guardian against oxidative stress, it is proposed that maintaining its integrity can support against telomere erosion and “stress-induced” premature onset of accelerated aging.

Scientific research suggests that a variety of consistent behaviors in humans in-vivo are available to alter the amount of oxidative stress placed on cells of the body.

Among factors thought to adversely affect telomeres are smoking, drinking heavily, obesity, and chronic psychological stress (1-3). On the other hand, meditation, socialization, and regular exercise are associated with longer telomeres (1-3).

In addition, studies suggest diet and supplementation habits can be help preserve telomere integrity. Some choices linked with longer telomeres are:

  • consuming higher amounts of omega-3 fatty acids
  • obtaining higher amounts of vitamin D, maintaining a healthy weight, eating a diet higher in dietary fiber (particularly insoluble fiber)
  • drinking green tea regularly
  • and taking a quality multivitamin (containing sufficient amounts of B vitamins, vitamins A, C, and E) daily (4)

Whey to Glutathione

Another method to gain optimal  protection against oxidative stress and telomere attrition is by using methods to naturally increase the levels of glutathione in the body by way of regular ingestion of whey protein, according to recent studies (5-7).

Bioactive whey protein,” as one study calls it, provides a high concentration of the amino acids cysteine, glutamate, and glycine. These amino acid precursors are used in the synthesis of glutathione by the enzyme GSH-synthase. Several studies have shown that bioactive whey protein can dramatically raise the levels of glutathione in the cells of the body without side effects (5 & 6). Increases in levels of circulating glutathione from whey are associated with a stronger immune system and greater capacity of detoxification.

Whey also offers other anti-aging benefits such as protection against sarcopenia (the loss of muscle and strength with age) and by supporting weight management through increases of thermogenesis and satiety.

Supplementing to Optimize Telomere Protection

Supplementing with antioxidant vitamins and minerals supports activity of antioxidant enzymes that can assist in protecting cells and their components, including telomeres, against oxidative stress.

GSH peroxidase plays a major role using GSH as its reducing agent in detoxification of peroxides (types of reactive oxygen species, such as hydrogen peroxide), which can inflict harm to cell membranes, proteins, and telomeric DNA.

The oxidized GSH is then recycled by another enzyme, GSH reductase, which uses nicotinamide adenine dinucleotide phosphate (NADPH) as its coenzyme and reducing agent. Catalase is also an enzyme that acts as an efficient detoxifier of hydrogen peroxide, while superoxide dismutases (SOD) are a class of enzymes that act to quench superoxide, a highly reactive form of oxygen, and convert it to hydrogen peroxide or stabilized oxygen.

It’s notable that selenium, niacin, zinc, and copper are important dietary factors because these enzymes rely on them to function.

Interestingly, data are emerging that particular dietary factors and supplements could act to promote antioxidant enzyme activity further and thereby further support telomere integrity. These supplements will be subject of future blog posts.

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More Information Product B including Ordering – Click Here!

Dr Bill Andrews Appears on NBC Today Show Discusses Telomeres and Telomerase.

Dr. Bill Andrews , was guest on an episode of the NBC Today Show. This particular show discussed aging research and how scientists were looking for solutions that could extend human lifespans up to 150 years old. The following video was taken from the show.

Watch Dr Bill Andrews NBC Today Show Telomeres video on YouTube – Click Here!

Dr Bill Andrews on Today Show

Dr. Andrews likes to say “Bad things happen when telomeres get short.” This Today Show segment detailed how Dr. Bill Andrews is working on finding a solution for extending human life, in effect overcoming aging. His research has focused on keeping telomeres from becoming short.

Order Information and More on Telomeres and Product B – Click Here!

IsaGenix Product B Telomeres Ingredients Video – Click Here!

Telomeres Science Facts and IsaGenix Product B

The Science of Telomeres is really very simple :

1. Telomeres are our ‘Body Clock’. They shorten with normal cell division.

  • They are caps of repetitive DNA at the ends of our chromosomes.
  • They shorten as the cells in our bodies divide.
  • 15,000 units long when we are conceived,
  • 10,000 units long when we are born,
  • Our telomeres continue to shorten with each cell division throughout our life, and when they get down to 5,000, WE DIE!

2. Telomerase is an enzyme that causes Telomeres to lengthen.

3. A Gene to produce Telomerase is present in every cell in our bodies.

4. Bad things happen when telomeres get short.

5. ‘Product B’ is a nutraceutical that contains substances that have been proven to support telomeres.

Here are some basic facts about IsaGenix Product B
IsaGenix Product B Telomeres bottle
It is a proprietary, scientifically advanced formula of antioxidants for protecting telomeres and stimulating more efficient antioxidant enzyme-defense systems.

As part of your body’s normal aging process, each time a cell divides the telomeres in your DNA get shorter. Add oxidative stress, obesity, poor nutrition, and toxicity to the mix and telomeres shorten even more rapidly.

Antioxidants fight free radicals and stem the causes of oxidative stress, but a key combination of antioxidants is needed to reduce the effects of oxidative stress on your telomeres.

Certain natural ingredients in Product B have been shown to induce telomerase in-vitro. In-vitro lab results may not be indicative of in-vivo results.

Here are some recent comments – what people are saying about Product B

”I have unbelievable energy!”

“I’m running around with toddlers and have energy to spare!”

“I have never felt better!”

“I began taking Product B in September 2010. The changes are both visible and invisible, but the biggest change is that I’ve lost all semblance of my age. If it weren’t for my driver’s license, I’d feel like I was 25. I have more energy, and every day I feel more and more alive. I went skiing recently and didn’t feel sore afterward.”
– Peter G

“My energy went through the roof. I recently went on a trip to Europe, and I didn’t feel sluggish with the time change.
Susan S.

“I’ve always been energetic, but with Product B I’m running faster and further. I’m so fired up about this product!”
Kathy C

Be sure to watch the Video of Bill Andrews on Telomeres, Product B and Aging – Click Here!

Another great telomeres resource is the following: This webpage analyzes the various botanicals contained in IsaGenix Product B – Click Here!

Here as an example is the writeup on Resveratrol Extract Nutrition Information – Click Here!

Telomere Telomerase Aging Research Dr. Bill Andrews

World Renown Aging Researcher Dr Bill Andrews has teamed with John Anderson of IsaGenix. They are working on a Telomerase Enzyme inducer scheduled for a preliminary release in June and a full release in August 2011.
Image of Telomeres
A new study on mice published in Scientific American has added validation to research that is being performed by Bill Andrews, Ph.D., who has partnered with Isagenix Founder John Anderson to “turn back the clock” on aging.

Their approach is to screen thousands of natural product compounds a week to turn on the enzyme, telomerase, in cells to protect telomere length and reverse its loss.

Telomeres are protective sequences of repetitive non-coding DNA segments found at the end of chromosomes. In recent years, telomere length has been hypothesized to be the closest way to measure lifespan in humans.
Telomerase study on Mice
In this latest study, Harvard Medical School researchers found that mice lacking telomerase aged much more rapidly, and died earlier, as an abundance of critically short telomeres developed. But when the enzyme was reawakened in the mice, age-related symptoms disappeared and rejuvenation was seen in several organs including their brains.

The study, which was led by geneticist Dr. Ronald Depinho, presents a strong case for advancing research for turning on telomerase in humans as a  potential anti-aging therapy.

In addition, Dr. Depinho explained that the study helps put concerns to rest that turning on telomerase was potentially cancerous.

Dr. Andrews adds, “This study is really just another nail in the coffin for the idea that telomerase induction would lead to cancer. Even as early as 2002, a review of 86 publications showed that telomerase is not a carcinogen or oncogene.”

In fact, telomerase stimulation is far from harmful, and in fact, has the potential to bring a new paradigm to what it means to age gracefully and achieve a healthier, longer life.

“Just as telomerase activation reversed degeneration in the organs of these mice, we expect that it can do the same for humans,” said Dr. Andrews. “Telomerase activation technology promises to be the most significant advance in human health since germ theory.”

Anderson said, “What we’re doing is going to change the world, but it shouldn’t be seen as a ‘holy grail,’ only another way of improving your health.” He explained that stimulation of telomerase should be used in conjunction with a healthy diet, optimal nutrition, nutritional cleansing, avoidance of toxic chemicals, and regular exercise.

Dr. Andrews and Anderson are launching a nutraceutical that will turn on telomerase exclusively through Isagenix in June with a full release in August 2011.

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